HydroxyPropyl Beta CyclodExtrin Hmoov

 

HydroxyPropyl Beta CyclodExtrin HmoovRaws li hydroxyalkylated derivative ntawm -cyclodextrin (-cd, cas}}}}} {} {})

 

Its toxicological characteristics have been verified by the OECD 423 acute toxicity test, with an LD50>5000 mg / kg (ntawm kev tswj xyuas kom nas), thiab nws tau teev ua Gras cov kws tshuaj saib USP-NF.

 

1. Solubility
With a hydrophobic cavity of 7.8-8.3 Å and a degree of substitution (MS) of 0.34-0.40, this molecule can increase the apparent solubility of poorly soluble drugs by 10²-10³ times.

 

2. Kev txhim kho biopharteutical
Los ntawm kev tsim 1: 1 lossis 1: 2 Inclus unclexes (khi tas li {{}} {5 5}} ⁴ m⁻¹), nws tau tiav:

 

• Txo cov nyhuv pib ua ntej: propranolol hepatic cov metabolism txo qis los ntawm 42%.
• Kev Tshaj Tawm Kev Tso Tawm Tawm: Ibuprofen Tmax tau txuas ntxiv los ntawm 1.2H rau 4.5H.
• Kev Tswj Xyuas Irritive: Acyclovir nce corneal thaum txo cov qhab nia zoo muag ntawm 78%.

 

 

1. HP─ ─CD muaj cov dej solubility siab ntawm chav sov, feem ntau tshaj 50%, yog li nws tsis tuaj yeem siv tshuaj hauv qab cawv.

 

2. HP─ ─CD thiab ─CD muaj cov kev xaiv sib txawv rau cov tshuaj sib txawv, thiab kev sib faib ntawm cov molecules hauv paus rau qee yam tshuaj yuav hloov pauv.

 

3. HydroxyPropyl Beta CyclodExtrin Hmoovyog yeej tsis yog catabolized tsis tau nce nyob rau hauv tib neeg lub cev. Feem ntau ntawm HP─ ─CD coj Oraly tswj tau yog ua rau cov quav. Thaum muab cov niam txiv ua haujlwm, yuav luag txhua tus HP─ ─CD tau tawm nrog cov zis.

 

4. HP─ ─CD tuaj yeem txhawb nqa kev tso tawm nrawm nrawm ntawm cov tshuaj hauv lub cev.

 

5. HP─ ─CD muaj qis dua cov haujlwm thiab hemolytic tshaj li ─CD lossis lwm yam kev sib tw, ua kom muaj kev nyab xeeb dua.

 

 

Yam ntsuas xyuas		Kev qhia tshwj xeeb	Qho kawg
Kev Qhia Txog Lub Cev
Kev tshwm sim		Dawb lossis yuav luag dawb, amorphous lossis crystalline hmoov. Dawb soluble hauv dej thiab hauv propylene glycolol.	Cov hmoov dawb
Clarity ntawm kev daws teeb meem		1. {{{{0 g / 2ml dej tov yog qhov tseeb thiab pob tshab	Ua raws
Mail Kheli		0.4~1.5	0.68
Tshuaj Ntsuam Xyuas
Daim qhia npe	Kuv	Tib txoj hlua haum ib yam li usp hydroxypropyl betadex Rs	Ua raws
	Clarity ntawm kev daws teeb meem	Yam zoo	Yam zoo
Betadex		1.5% Max	0.37%
Propylene Glycol		2.5% Max	0.05%
Lwm tus impurity		{{0 {}}. 25% Max	Tsis pom
Tag nrho cov kab laum tsis suav nrog cov betadex thiab propylene glycol		1. {0 max	Tsis pom
Propylene Oxide		0. 0001% Max	0.000012%
Kev coj ua		200μs / cm Max	70μs / cm
Poob rau ziab		1 {0. 0% Max	3.2%
Kev tswj cov microbiology
Tag nrho aerobic microbial suav		1000cfu / g max	<10cfu/g
Tag nrho cov pwm thiab cov poov xab		100cfu / g max	<10cfu/g
Tag		Ua raws cov qauv.
Ntim thiab Ntim
Pob: Pob hauv ntawv-thawv thiab ob daim yas yas-hauv sab hauv.
Txee lub neej: 2 xyoo thaum khaws cia kom zoo.
Cia: Muab cia rau hauv ib qho chaw kaw zoo nrog qhov kub tsis tu ncua thiab tsis muaj hnub ci ntsa iab.

 

 

1. Kws kho mob teb:
Vim nws cov kev ua haujlwm tsawg tsawg thiab hemolytic ua haujlwm thiab tsis muaj kev voos rau cov leeg,HydroxyPropyl Beta CyclodExtrin Hmoovyog ib qho zoo tshaj plaws ntawm cov khoom siv thiab cov tshuaj kom zoo rau kev txhaj tshuaj.

 

Nws tuaj yeem txhim kho cov dej solubility ntawm cov tshuaj tsis zoo, txhim kho kev ua yeeb yam ntawm cov tshuaj, nce kev ua kom muaj tshuaj lom neeg, thiab txo cov tshuaj lom thiab muaj kev phiv tshuaj los ntawm cov tshuaj.

 

2. Khoom Noj Khoom Haus:
Hydroxypropyl beta-Cyclodextrin tuaj yeem txhim kho cov kev ruaj khov thiab saj cov khoom noj tsis zoo thiab saj cov txheej txheem khoom noj khoom haus thiab khoom siv ntau lawm thiab cov khoom lag luam zoo.

 

3. Tshuaj pleev ib ce teb:
HydroxyPropyl Beta CyclodExtrin Hmoov yog siv los ua cov tawv nqaij tawv, thiab lwm yam kev ruaj khov ntawm cov khoom xyaw thiab oxidation ntawm cov as-ham. Nws kuj tseem muaj qee qib ntawm kev sib txheeb ntawm hygroscopicity.

 

 

1. Cov ntaub ntawv yooj yim

 

Yam zoo	HydroxyPropyl Beta Cyclododextrin	Hydroxypropyl gamma cyclodextrin
Lub tsev	-Cyclodextrin (7 chav dej qab zib)	-CYYCLODEXTREXTRECH (8 HAZO HAZE UNITS)
HydroxyPropny Site Site	Feem ntau tshwm sim ntawm C2 thiab C6 Hydroxyl txoj haujlwm	Xum nyob c3 hydroxyl txoj hauj lwm
Cavity ntim	262 ų	427 ų
Topological Polarity	Electrostatic muaj peev xwm sib txawv ntawm cov kab noj hniav saum npoo ψ {0}}. 7 kv / m	Ψψ {=12. 3 KV / m (ntau dua haum rau hluav taws xob molecules)

 

2. Kev sib piv ntawm cov kev ua tau tseem ceeb

1. Kev tshem tawm thiab ruaj khov
(1) HydroxyPropyl Beta CyclodExtrin Hmoov:

• DEJ Solubility ncav cuag 60 G / 100ML (25 degree), tab sis micelles tau tsim yooj yim hauv cov ionic lub zog kev daws teeb meem.
• Lub thermal decomposition kub yog nce rau 315 degree, thaum tus thawj -cd yog 290 degree.

 

(2) HP - - CD:

• Lub solubility tshaj 80 g / 100ml, thiab nws tuaj yeem ua siab ntev pH {2}} pam acid stability yog hloov kho los ntawm 300%).
• Oxidative Indusion Performance index (OSI) nce mus txog 42 teev, thaum hp - - Cd tsuas mus txog 28 teev.

 

 

1. Kws ua teb

 

(1) HP - - CD:

• Lub zog tseem ceeb hauv solubilizing me me molecule tshuaj.
• Transdermal thaj optimization: nce estradiol transdermal tus nqi los ntawm 220%.
• Cov kev txwv: Tsawg dua raum clearance (cl {0}}. 32 L / KG).

 

(2) HP - - CD:

• Macromolecule Kev xa tshuaj: pd {-1 antibodody tau ua tiav, thiab kev txhaj tshuaj tiv thaiv kev nkag mus txog 81%.
• CARRIER CARRIER CARD: siv hauv tsheb-try can canopreservation daws kom nce cov ciaj sia ntawm 40% rau 92%.
• Kev Siv Breakfroughibh: cov ntshav-lub hlwb thaiv kev nkag tau zoo yog 7 zaug ntawm hp - - CD.

 

2. Khoom noj khoom haus thiab tshuaj pleev ib ce

 

(1) HydroxyPropyl Beta CyclodExtrin Hmoov:

• Kev txhawb nqa cov tshuaj tsw qab: tus nqi khaws cia ntawm Citrus tseem ceeb roj tseem yog 95% tom qab 6 lub hlis.
• Sunscreen stabilization: txo cov avoBenzone phoerogradation tus nqi los ntawm 78%.

 

(2) HP - - CD:

• Cov roj ua haujlwm roj ua haujlwm: cov oxidation induction lub sij hawm ntawm omega -3 filty acids yog txuas ntxiv mus rau 18 lub hlis.
• Kev zoo nkauj tiag tiag zoo nkauj: nruab nrog Sergna, kev ua haujlwm ntawm kev nkag mus rau hauv lub tsev loj stratum yog nce los ntawm 60 lub sijhawm.

 

 

Txiv milerco tuaj yeem muab cov kev xa khoom siv tau thiab yooj yim rau cov khoom uas cov neeg siv khoom xav tau. Piv txwv li: huab cua, hiav txwv, nthuav qhia, koj tuaj yeem so kom paub txog cov khoom muaj teeb meem zoo thaum muaj kev thauj mus los.

 

Peb muaj cov neeg ua haujlwm ua lag luam ua kev sib txuas lus nrog koj txog koj cov khoom xav tau thiab nkag siab. Muaj cov ntawv xa ntawv tshaj lij, koj tuaj yeem tso cov lus thaum lub sijhawm twg los, peb yuav teb tau sai li sai tau peb pom. Yog tias koj muaj cov khoom xav tau, koj tuaj yeem tso cov lus thaum txhua lub sijhawm thiab peb yuav teb sai li sai tau peb pom nws. Tiv tauj peb kom paub meej ntxiv: Email: info@fruiterco.com.

 

 

Cim npe nrov: HydroxyPropyl Beta CyclodExtrin Hmoov, Tuam Tshoj HydroxyPropyl Beta Cyclodearextrin Hmoov Manufacturers, lwm tus neeg, Hoobkas